• br Androgen interference with the action

  2023-09-07

  

  Androgen interference with the action of arachidonic salbutamol sulfate metabolites’ actions; the other side of the coin Arachidonic acid, being a polyunsaturated fatty acid present in the phospholipids of the membrane of cells, is highly abundant within the organism. It is mainly involved in cel

• br Conclusions br Transparency document br

  2023-09-07

  

  Conclusions Transparency document Acknowledgements This work was supported by a grant from the European Commission FP6 “Neuroprion” – Network of Excellence and Royal Veterinary College Bioveterinary science research project funding. We thank Professor Alun Williams (Cambridge University) fo

• The first and the best characterized mechanism of receptor d

  2023-09-07

  

  The first and the best-characterized mechanism of receptor-dependent internalization of Aβ is mediated via the α7-nicotinic histamine inhibitors receptor [82]. Lipoprotein receptor protein represents the second best-studied route that facilitates the uptake of Aβ by neurons, involving additional mol

• The AMP Activated Protein Kinase AMPK has evolved as an

  2023-09-07

  

  The 5′AMP-Activated Protein Kinase (AMPK) has evolved as an important cellular sensor of reduced energy status that can subsequently phosphorylate its target proteins, slowing the rates of key biosynthetic processes and promoting energy producing pathways; for these reasons AMPK has been proposed as

• The rescue of the behavioral deficit was

  2023-09-07

  

  The rescue of the behavioral deficit was associated with a significant reduction in the levels of both soluble and insoluble Aβ peptides and their deposition in the PI-3065 australia of the same animals. In search for the mechanism behind the reduced amyloidosis, we assessed APP metabolism. Confirm

• ESI-09 Differentiation of skeletal myoblasts is a tightly or

  2023-09-07

  

  Differentiation of skeletal myoblasts is a tightly orchestrated process that involves myoblast proliferation, ESI-09 withdrawal, expression of muscle-specific genes, and fusion into multinucleated myofibers (Horsley and Pavlath, 2004; Krauss, 2010). The maintenance of muscle mass is important for s

• Curcumin is able to upregulate

  2023-09-07

  

  Curcumin is able to upregulate the protein level of NGF through cannabinoid receptor CB1, where the activation of Akt pathway probably plays an important part in the CB1-mediated signal transmission [9,10]. This finding suggested that the protection of curcumin in spinal motor neurons of SNI rats i

• Polycyclic aromatic hydrocarbons PAHs are abundant environme

  2023-09-07

  

  Polycyclic aromatic hydrocarbons (PAHs) are abundant environmental contaminants that are produced by the incomplete combustion of organic matter, combustion engines, residential heating, ionophores burning, and industrial activities (Gelboin, 1980; Phillips, 1999, Phillips, 2002). Some PAHs have be

• Most of the modifications in the sympathetic nervous system

  2023-09-07

  

  Most of the modifications in the sympathetic nervous system occurring with aging, including decreased βAR responsiveness, increased circulating catecholamines, and overall hyposensitivity to adrenergic stress, are also observed in patients with failing hearts. Moreover, young people are more reactiv

• There are human genes in

  2023-09-07

  

  There are 12 human genes in the SLC5A family, and 6 of these are expressed in human heart (Table 2). Little is known about SGLT proteins in the heart. Zhou et al. [56] reported the presence of SGLT1 mRNA in the human heart. Researchers have found that levels of SGLT1 mRNA in heart are approximately

• br Theoretical mechanism of ABCA activity in LE

  2023-09-07

  

  Theoretical mechanism of ABCA2 activity in LE/LY in modulation of cholesterol trafficking It is important to confirm that ABCA2 is a lipid transporter and identify the substrates that are mechanistic in its cholesterol sequestering activity. We hypothesize that ABCA2 modulates cholesterol sequest

• br ABCA is a sterol responsive gene

  2023-09-07

  

  ABCA2 is a sterol-responsive gene The first evidence to demonstrate that ABCA2 expression responded to sterol loading was provided in an experiment involving monocyte to macrophage differentiation in vitro. Upon sterol loading with enzymatically degraded LDL (eLDL), ABCA2 expression increased onl

• br Actin cytoskeleton in protrusion

  2023-09-07

  

  Actin cytoskeleton in protrusion Pushing force driving membrane protrusion is generated by polymerizing p16 filaments organized either into branched networks or parallel bundles. Branched networks are assembled through Arp2/3 complex-dependent actin nucleation and drive protrusion of lamellipodi

• br Results br Discussion The

  2023-09-07

  

  Results Discussion The present study uncovers a role of calpain, a family of calcium-dependent protease, in regulating postsynaptic differentiation at the NMJ. Cholinergic activation stimulates calpain, whose inhibition stabilizes AChR clusters in cultured muscle GSK180 and in agrin mutant mic

• br Introduction Nausea and vomiting are among

  2023-09-07

  

  Introduction Nausea and vomiting are among the most distressing side effects associated with chemotherapy in cancer patients (Billio et al., 2010). Severe emesis can negatively affect a patient's nutritional state, ability to work and motivation, which can, in turn, interfere with the clinical co

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