• We found that infants with severe SGA had a

  2020-07-31

  

  We found that infants with severe SGA had a higher incidence of abnormal CpG1 methylation in the placenta, though there was no significant difference in the average methylation of each CpG site among the three groups. It is noteworthy that not only hypomethylation but also hypermethylation were pred

• A putative SHBG receptor SHBG R has been

  2020-07-31

  

  A putative SHBG Neuropeptide Y 13-36 (porcine) (SHBG-R) has been postulated for about thirty years [66], [69], [70]. The characterization of this receptor has been researched by several groups. There are different ideas on how this receptor works. On the one hand Fortunati et al. provide evidence t

• fexofenadine hydrochloride The second challenge is to

  2020-07-31

  

  The second challenge is to identify biomarkers that accurately forecast treatment outcome [134]. Our institutional experience from several advanced cancers suggests that therapies matching underlying actionable somatic mutations can improve outcomes compared to unmatched therapies [135]. Unfortunate

• (-)-epicatechin EBI and its ligand s EBI was found in a

  2020-07-31

  

  EBI2 and its ligand(s) EBI2 was found in a screen of upregulated genes in human (-)-epicatechin upon infection with EBV [1]. EBI2 is a G-protein (Gαi type) coupled receptor [2] but as long as 18 years after its discovery the nature of its ligand remained undisclosed. With the help of transfected c

• Initially the doxorubicin fluorescence assay demonstrated th

  2020-07-31

  

  Initially, the doxorubicin fluorescence assay demonstrated that NU7441 induces doxorubicin accumulation in a concentration-dependent manner in paired wild-type and MDR1-overexpressing MDCKII cells. The kinase inhibitor sorafenib is used to treat advanced renal cell carcinoma [33] and hepatocellular

• The unique property of mutant

  2020-07-31

  

  The unique property of mutant IDH1/2 in producing an oncometabolite that has no known physiological function makes mutant IDH SZL P1-41 synthesis as obvious potential therapeutic targets for the treatment of IDH-mutated tumors (Rohle et al., 2013, Wang et al., 2013). Clinical studies have also sugg

• br Conflicts of interest br Author

  2020-07-30

  

  Conflicts of interest Author contributions Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorde

• Discussion In summary we have

  2020-07-30

  

  Discussion In summary, we have introduced and characterized a ubiquitin point mutant capable of conjugating to cognate substrates and incorporating into ubiquitin chains, yet remains refractory to cleavage by DUBs. This provides a unique tool to enable the generation, identification, and study of s

• N Alkylated quinolinium dyes are

  2020-07-30

  

  N-Alkylated quinolinium dyes are the common fluorescence molecules used in fluorescence sensing and cell imaging because of their attractive optical properties as well as high DNA binding affinities.13, 14, 15, 16, 17, 18, 19, 20 Moreover, the quinolinium moiety usually plays the role of donor in va

• The aim of this work is to explore

  2020-07-30

  

  The aim of this work is to explore different recycling bombesin receptor as fusion partner for two oxidoreductase enzymes (BVMO and ADH), and to compare their strengths and weaknesses for biocatalytic applications. We fused three different regenerating enzymes to a BVMO (TmCHMO, from Thermocrispum

• The hypermethylation of DNA is a key epigenetic mechanism

  2020-07-30

  

  The hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes responsible for Lonafarnib regulation, inflammatory and stress response, DNA repair and apoptosis. Hypermethylation of certain genes, particularly tumor suppressor genes, is known to be associated with the ina

• Previously we reported the structure activity relationships

  2020-07-30

  

  Previously, we reported the structure–activity-relationships (SAR) of a series of pyrazinone-based CRF receptor antagonists, , , leading to highly potent and efficacious compounds such as , and ultimately to the discovery of (BMS-764459, ). Detailed SAR studies of the lower phenyl/pyridyl substitu

• br Acknowledgements This work was supported by funding from

  2020-07-30

  

  Acknowledgements This work was supported by funding from the Natural Sciences and Engineering Research Council of Canada (RGPIN-2017-06346 to JB), National Institute of Child Health and Human Development (5R01HD083930-02 to JB), and the National Institute of Biomedical Imaging and Bioengineering

• br Transparency declaration The authors declare no conflict

  2020-07-30

  

  Transparency declaration The authors declare no conflict of interest. This study was funded by from the Instituto de Salud Carlos III (grant number: PI11-02800; PI11-01357; PI14-00165), and co-financed by European Development Regional Fund ‘A way to achieve Europe’ ERDF, Spanish Network for the R

• Currently over RNA or DNA base modifications are known

  2020-07-29

  

  Currently, over 110 RNA or DNA SKL2001 modifications are known, which are introduced by specific modifying enzymes and are important for gene expression, translation, DNA repair, stress response, and host-pathogen interactions (Cantara et al., 2011). The pseudouridine (Ψ), 5-methyluridine (m5U), 5-

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